HPLC purity test
Reversed-phase HPLC quantifies the main content and related substances. It is the core method for assigning the ≥98% purity grade and detects homologous impurities and residual glycoluril.
About Cucurbituril-X
Focused on supramolecular materials, delivering high-quality cucurbituril products for scientific innovation
Platform Overview
Cucurbituril-X.com is a professional research supply platform specializing in the supramolecular cucurbituril series. We provide high-purity cucurbit[n]urils and their derivatives to researchers worldwide, including standard products such as CB[5], CB[6], CB[7], CB[8] and functionalized variants like methylated, cyclohexyl, and cyclobutyl derivatives.
Our Mission
Our mission is to make cucurbituril materials more accessible to researchers worldwide and to encourage broader exploration and innovation in cucurbituril-based supramolecular chemistry.
Professional R&D Team
Senior supramolecular chemistry experts with extensive experience in cucurbituril synthesis and application research
Strict Quality Control
Comprehensive quality testing ensures each batch meets purity standards above 98%
Research Collaboration Network
Long-term partnerships with renowned domestic and international universities and research institutions
Industry Certifications
Certified by relevant quality management systems to meet research material supply standards
Quality Control Process
01
Raw Material Selection
Strictly select high-purity raw materials
02
Synthesis Control
Standardized synthesis process
03
Purification
Multiple purification techniques ensure high purity
04
Quality Testing
Multi-method testing including NMR and HPLC
Analytical and Quality Control Methods
Purity assignment for cucurbiturils cannot rely on a single technique: homologue distribution, degree of substitution, lattice water, and residual solvent all affect usable concentration in practice. We verify every batch using mutually corroborating methods. All regular and modified products on this site meet a uniform ≥98% purity grade.
NMR structural confirmation
¹H and ¹³C NMR confirm the glycoluril skeleton, substitution pattern, and degree of substitution. For methylated, cyclohexyl, and cyclobutyl products, integration ratios directly verify complete substitution.
Mass spectrometry for molecular weight
ESI-MS or HRMS verifies the molecular ion against the theoretical mass and rapidly identifies the main component and impurity profile in homologue mixtures such as CB[n] distributions.
Elemental analysis and water content
C/H/N elemental analysis confirms composition and lattice water count, while Karl Fischer titration measures water content. Since cucurbiturils typically exist as hydrates, both values are essential for accurate molar concentration calculations.
Why We Focus on Cucurbiturils
Among supramolecular hosts, cucurbiturils feature a rigid cavity with carbonyl-fringed portals that enable a unique recognition mode: hydrophobic driving force combined with strong ion–dipole and hydrogen-bonding interactions. This results in distinct affinity and size selectivity compared to other macrocyclic families, which is why we have chosen to focus on this field long term.
| Macrocyclic host | Cavity character | Typical Ka range | Size series | Portal groups |
|---|---|---|---|---|
| Cucurbit[n]uril (CB[n]) | Rigid barrel cavity with carbonyl-fringed portals | 10⁴–10¹² M⁻¹ | CB[5]–CB[10] | Carbonyl C=O (electron-rich, cationophilic) |
| Cyclodextrin (CD) | Conical cavity with moderate flexibility, enabling induced fit | 10²–10⁴ M⁻¹ | alpha / beta / gamma | Secondary / primary hydroxyl groups |
| Calix[n]arene | Shallow cup, tunable conformation, typically derivatized | 10²–10⁵ M⁻¹ | n = 4–8 | Phenolic hydroxyl groups (modifiable) |
| Cucurbit[n]uril | Pillar-shaped electron-rich cavity | 10³–10⁶ M⁻¹ | n = 5, 6 is primary | Alkoxy groups |
Association constants reflect typical literature ranges. Actual values depend heavily on guest structure, solvent, pH, and ionic strength—always refer to measurements from your own system.
Explore our products and services
- Product catalog: CB[5]–CB[10] and modified seriesCAS number, formula, purity, pack sizes, and pricing for each homologue.
- Comparison of properties among cucurbit[n]uril homologuesCavity volume, portal diameter, outer diameter, and height.
- Custom synthesis serviceSpecial substitution patterns, specific homologues, milligram-to-gram scale.
- Research resources and literatureAdvances in drug delivery, sensing, catalysis, and materials research.
Work with our technical team
- Contact us for a quoteEmail jl.zhao@ziat.ac.cn, phone, or the online form — replies sent on business days.
- Request batch analytical dataPurity, water content, and spectral data for the relevant batch prior to ordering.
- Storage, solubility, and handling notesDissolution pathways, stock preparation guidance, and record-keeping instructions by homologue.
- Cucurbituril selection guideSelect by guest size, solvent system, application, and scale.
Contact Us
For technical collaboration or product inquiries, contact our professional team.