Professional team delivers customized synthesis solutions for cucurbituril compounds.
We operate dedicated synthesis laboratories with an experienced R&D team, offering custom synthesis for a broad range of cucurbituril derivatives. We support production scales from milligrams to grams, ensuring uniform purity of ≥98% (by HPLC) and providing a batch-specific analytical report with every order.
Customizable types include methylated cucurbiturils, cyclohexyl cucurbiturils, cyclobutyl cucurbiturils, and other functionalized derivatives.
Unsubstituted cucurbit[n]urils have limited solubility in common organic solvents and pure water, often the first hurdle when designing an experiment. Adding substituents to the outer wall or fusing rings onto glycoluril units can significantly improve solubility while largely preserving cavity size and portal carbonyl recognition. Below are strategies we have already developed and can customize upon request — you may reference them by name when submitting an inquiry.
Unsubstituted CB[5] and CB[6] form dense intermolecular hydrogen-bond networks, dissolve poorly in water and most organic solvents, making concentrated aqueous host solutions difficult to prepare and limiting their biological and solution-phase applications.
Introducing methyl groups onto the glycoluril skeleton (TMeCB[6], Me10CB[5], Me12CB[6]) disrupts intermolecular hydrogen-bond packing, significantly enhances water solubility, and largely preserves the rigid cavity and carbonyl-portal recognition behavior.
The cyclohexano-fused series (Cy5CB[5], Cy6CB[6], 1,3,5-Cy3CB[6]) enhances solubility and processability via outwardly projecting cyclohexane rings. Cavity dimensions remain comparable to the parent homologues, so established host–guest design rules still apply.
The cyclobutano-fused series (CyB5CB[5], CyB6CB[6]) offers excellent water and alcohol solubility, making it ideal for water/alcohol mixed solvents, coating formulations, and workflows requiring an organic co-solvent.
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Custom synthesis per standard procedures
Rigorous quality control before safe delivery
